Are in vitro antimalarial assays a waste of time?

In vitro efficiency does not guarantee in vivo

Most of the assessments on the antimalarial efficacy of a molecule are made in vitro. In the case of plant material, the first step is generally the extraction with an organic solvent. The extract is then lyophilized, frozen and stored for subsequent trials. A recent research paper from the University of Al Quds Akkawi M, Jaber S, Abu-Remeleh Q, Engeu OP, Lutgen P (2014) . Investigations of Artemisia Annua and Artemisia sieberi Water Extracts Inhibitory Effects on β-Hematin Formation. Med Aromat Plants 3: 150. doi:...

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Serbian or Chinese invention of artemisinin

Jeremic o Yoututu

Artemisia annua came under the spotlight during the Vietnam War. Viêt-Cong who operated in swamps and rain forests lost more soldiers by mosquito bites than by American bullets. Ho Chi Min turned to China for help. Researchers at the Chinese Institute of Material Medicine had found a region of China that reported no malaria cases, and when they investigated, they discovered that its people drank a decoction of Artemisia annua at the first symptoms of malaria. And actually, wild Artemisia has been used for millenniums in several regions of...

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Taurine in malaria

Why mothers milk is better than cow or instant milk

Or why cats and dogs are malariafree. Taurine, a sulfur-containing amino acid, is the most abundant amino acid in mammals, occurring both in cells and in blood plasma. High concentrations of taurine are found in the heart, retina, bile, brain, plasma, platelets, leucocytes, whereas smaller amounts are found in liver, erythrocytes, muscles, kidney. Cécile Petton. La taurine: point sur ses propriétés et son utilization en 2011. Thèse de doctorat. Université dde Nantes 2011. Taurine may protect cells against various types of...

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Very efficient prophylaxis with Artemisia; another Congolese breakthrough

Prophylaxe mit Artemisia afra

Jérôme Munyangi, Lucile Cornet-Vernet, Pierre Lutgen 4 years ago, a heated debate concerning malaria prophylaxis had been triggered on It concerned the very promising results obtained by Dr Patrick Ogwang, with an herbal product called Artavol, he had developed with the Ministry of Health in Uganda. Peer reviewed papers and press releases are easily found on internet. Merlin Willcox, UK, Honorary Secretary of RITAM, questioned the validity of the therapeutic and prophylactic results obtained by the research...

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RTS vaccines: 20 years of false hopes

RTS: ein Impfstoff ohne Hoffnung

The first results of the RTS,S vaccine already appeared in 1998 in a scientific paper. The conclusion was: Immune responses did not correlate with protection. Further optimization in vaccine composition will be required to induce longer-lasting protective immunity. Stoute JA, Kester KE, Ballou Wr. Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine. J Infect Dis. 1998 178(4), 1139-44 Another randomised trial of the efficacy of RTS,S against natural P. falciparum infection in semi-immune adult...

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